Liquor Store Blues by Bruno Mars is a reggae-influenced track that speaks to themes of escapism and emotional struggles. The song features Mars singing about using alcohol as a way to cope with life's difficulties and momentarily escape from his troubles. Key themes include addiction, sorrow, and the desire to find relief from pain. Particularly poignant moments in the song include lines that describe the overwhelming sense of being trapped in one's circumstances and seeking solace at a liquor store. The collaboration with Damian Marley adds a deeper layer, emphasizing both artists' shared sense of grappling with life's hardships.