Indie Rock & Roll by The Killers is a celebration and critique of the indie music scene, capturing the spirit of youthful rebellion and the dream of becoming a rock star. The song emphasizes themes of freedom, individuality, and the desire to break free from conventional norms to follow one's passion. It juxtaposes the glamorous yet rough reality of the music lifestyle, reflecting both the allure and the struggles inherent in chasing one's dreams. Key moments in the song highlight the band's personal connection to the indie rock identity and the pride they take in being part of that world.