The Set-Up by Zebrahead is a high-energy punk rock anthem that delves into themes of betrayal and disappointment. The song narrates the experience of feeling deceived and let down by someone close, emphasizing the emotional turmoil that follows such a betrayal. The raw lyrics and intense musical composition reflect the frustration and anger associated with being 'set-up' or tricked by someone trusted. Poignant moments in the song include lines that highlight the internal struggle and the realization of being manipulated, striking a powerful chord with listeners who have faced similar experiences.