You Only Live Once by The Strokes is an engaging song that delivers a message about living life to the fullest and not being held back by fears or regrets. The lyrics reflect themes of seizing the moment, breaking free from social constraints, and the existential recognition that life is fleeting and precious. Key themes include carpe diem, individuality, and rebellion against conformity. Poignant moments in the song include lines that emphasize the importance of personal freedom and the urgency of making the most out of one’s limited time, capturing the essence of youthful defiance and determination to live authentically.