Ask Me Anything by The Strokes is a contemplative song that reflects themes of uncertainty, introspection, and disillusionment. The lyrics suggest a sense of searching for answers and dealing with the pressure of expectations. The song captures a feeling of vulnerability and the struggle to find meaning in a complex world. Wordplay in lines like 'I've got nothing to say' emphasizes the futility found in certain aspects of life, adding a poignant touch to the song.