Last Nite by The Strokes is a song that delves into themes of disillusionment, relationships, and self-awareness. The lyrics discuss a night out and the emotions that come with it, highlighting a sense of youth and rebellion. The chorus reflects on feelings of regret and realization, emphasizing the inevitable passage of time and change in personal dynamics. Key moments in the song include the repeated phrase 'Last night', which underscores the fleeting nature of experiences and the epiphanies that can come with them.