The song 'The Medication Is Wearing Off' by Eels delves into themes of mental health and emotional vulnerability. It captures the feeling of dependence on medication to regulate moods and the ensuing vulnerability when its effects begin to fade. Key themes include the fragility of emotional stability and the struggles of facing raw, unfiltered emotions. Particularly poignant moments in the song include the descriptions of the internal battles and the profound sense of discomfort that comes with emotional exposure.