It's a Motherfucker by Eels is a poignant ballad that deals with themes of loss, heartbreak, and the pain of missing someone deeply. The song's lyrics are raw and reflective, conveying a sense of vulnerability and sadness. It highlights the struggle of coming to terms with the absence of a loved one and the emotional toll it takes. Key moments in the song include the repeated use of the phrase 'It's a motherfucker,' which underscores the intensity of the emotions involved. Another poignant aspect is the simple yet powerful instrumental arrangement, which complements the somber tone of the lyrics and amplifies the feeling of melancholy.