That's Not The Issue by Wilco is a song that delves into themes of self-assurance and dismissing trivial matters. The lyrics suggest a sense of confidence and a focus on what truly matters, disregarding minor problems and external opinions. The key themes include self-empowerment, resilience, and the prioritization of significant aspects of life over inconsequential issues. Poignant moments include the repetition of the phrase 'that's not the issue,' which underscores the central message of concentrating on the bigger picture.