'How To Fight Loneliness' by Wilco explores themes of isolation and the coping mechanisms people use to combat feelings of loneliness. The song suggests that sometimes we mask our true emotions with a smile to hide inner sadness. It offers a bittersweet reflection on the human tendency to suppress and conceal pain, focusing on pretense and pretending that everything is okay. Key moments include the lines 'Just smile all the time' and 'You laugh at every joke, drag your blanket blindly,' which underscore the idea of superficial coping strategies. The lyrics encourage listeners to consider the disconnect between external appearances and internal realities.