I Can't Win by The Strokes is a reflection on personal struggles and feelings of defeat. Julian Casablancas' lyrics convey themes of frustration, disillusionment, and existential angst. The song delves into the complexities of relationships and the sense of inevitably failing despite efforts. Key moments in the song include the recurring lines 'I can't win' which serve as a powerful refrain underscoring the sense of inevitable defeat, and the introspective verses that talk about attempts to cope with life's hardships. The poignant delivery and raw emotion in the performance add to the depth of the song's message.