Glamorous Indie Rock & Roll by The Killers is a spirited celebration of the indie rock lifestyle, portraying it as an exciting and glamorous culture. The song highlights themes of freedom, rebellion, and the pursuit of passion over materialism. It emphasizes a carefree, youthful energy and embraces an alternative way of life free from mainstream constraints. Poignant moments include the repeated emphasis on the 'glamorous' aspect of indie rock and the juxtaposition of this with a sense of authenticity and originality. The song is an anthem for those who find beauty in the non-conventional and who prioritize artistic integrity over commercial success.