Blessed by Simon and Garfunkel is a profound exploration of existential angst and spiritual disillusionment. The song delves into the contrast between perceived blessings and the stark reality of life's hardships. Key themes include the search for meaning, the struggle with faith, and societal alienation. Particularly poignant moments in the song include the lines where the singer recounts encounters with marginalized individuals, reflecting on their own sense of lost innocence and spiritual bewilderment.