Sign Me Up by Ne-Yo is a song about the excitement and desire that come with new romantic interests. Ne-Yo expresses a willingness to dive into a relationship and fully commit, metaphorically asking to be signed up for love. Key themes of the song include romantic commitment, the thrill of potential love, and eagerness to start a new romantic journey. Particularly poignant moments in the song emphasize Ne-Yo's readiness to embrace love and his determination to give his all to a blossoming relationship.