You & I by Jeff Buckley is a soulful song that revolves around themes of love, longing, and intimacy. The lyrics delve into the deep connection between two people, reflecting on both the beauty and pain that come with intense relationships. Key themes include the yearning for closeness, the inevitability of separation, and the lingering impact of love on one's soul. Poignant moments in the song highlight the vulnerability of the singer, as he expresses sincere emotions and a desire for unity with his partner.