Me And My Guitar by James Taylor is about the deep and personal connection between the artist and his guitar. The song explores themes of companionship, creativity, and solace, portraying the guitar as not just an instrument but a loyal friend and a source of comfort. This heartfelt bond is reflected in the lyrics, illustrating how the guitar provides both an outlet for emotional expression and a sense of identity. Particularly poignant moments in the song include references to the guitar helping the artist through tough times and being a constant presence in his life, highlighting the therapeutic and life-affirming power of music.