Talking To Mary by Elliott Smith explores themes of loneliness, substance abuse, and internal struggle. The song is a poignant reflection on how relationships can provide temporary solace but may not be enough to overcome deeper personal issues. Key themes include isolation, the fleeting nature of comfort, and the difficulty of personal transformation. Particularly poignant moments in the song include the expressions of desperation and the search for understanding amidst personal turmoil, highlighting Smith's deep emotional and psychological conflicts.