The song 'People Come, People Go' by David Guetta delves into the transient nature of human relationships and experiences. It reflects on the ebb and flow of people entering and exiting one's life, capturing the inevitable changes and the impermanence of connections. Themes include the passage of time, the fleeting nature of relationships, and the acceptance of life's continuous changes. Poignant moments include reflective verses about saying goodbye and embracing new beginnings, underlining the cyclical patterns of meeting and parting with others.