Put Your Dukes Up, John by Arctic Monkeys is a song that delves into themes of confrontation, confidence, and resilience. The lyrics portray a scenario where the protagonist, John, is encouraged to stand up and face his challenges, suggesting a metaphor for dealing with adversities and not backing down from confrontations. Key themes include bravery, defiance, and the belief in one's own abilities. Particularly poignant moments in the song include the repeated refrain encouraging John to 'put his dukes up,' which serves as a rallying cry to face difficulties head-on, embodying a sense of empowerment and determination.