Harlem's Nocturne by Alicia Keys is a soulful and reflective track that delves into the struggles and emotional nuances of life in Harlem. This song paints a vivid picture of the longing for change and the introspective journey of overcoming personal and social hardships. Key themes include resilience, hope, and the quest for a better future. Some particularly poignant moments in the song include lyrical imagery that captures the essence of urban life and the emotional depth of pursuing one's dreams despite obstacles.