Chemical Addiction by Alice In Chains delves into the dark and haunting world of substance abuse and its gripping effects on individuals. The song explores themes of dependency, inner turmoil, and the struggle to break free from the clutches of addiction. Key moments in the song highlight the emotional and physical tolls addiction takes on a person, as well as the cycle of despair it perpetuates. The lyrics serve as a gritty commentary on the battle between wanting to escape the pain and the lure of the substances that temporarily mask it.